Publications of Dagny Grzech

Grzech, D.; Smit, S. J.; Alam, R. M.; Boccia, M.; Nakamura, Y.; Hong, B.; Barbole, R.; Heinicke, S.; Kunert, M.; Seibt, W. et al.; Grabe, V.; Caputi, L.; Lichman, B. R.; O’Connor, S. E.; Aharoni, A.; Sonawane, P. D.: Incorporation of nitrogen in antinutritional Solanum alkaloid biosynthesis. Nature Chemical Biology 21, pp. 131 - 142 (2025)

Boccia, M.; Kessler, D.; Seibt, W.; Grabe, V.; Rodriguez Lopez, C. E.; Grzech, D.; Heinicke, S.; O’Connor, S. E.; Sonawane, P. D.: A scaffold protein manages the biosynthesis of steroidal defense metabolites in plants. Science 386 (6728), pp. 1366 - 1372 (2024)

Schotte, C.; Jiang, Y.; Grzech, D.; Dang, T.-T. T.; Laforest, L. C.; León, F.; Mottinelli, M.; Nadakuduti, S. S.; McCurdy, C. R.; O’Connor, S. E.: Directed biosynthesis of mitragynine stereoisomers. Journal of the American Chemical Society 145 (9), pp. 4957 - 4963 (2023)

Nguyen, T.-A. M.; Grzech, D.; Chung, K.; Xia, Z.; Nguyen, T.-D.; Dang, T.-T. T.: Discovery of a cytochrome P450 enzyme catalyzing the formation of spirooxindole alkaloid scaffold. Frontiers in Plant Science 14, 1125158 (2023)

Grzech, D.; Hong, B.; Caputi, L.; Sonawane, P. D.; O’Connor, S. E.: Engineering the biosynthesis of late-stage vinblastine precursors precondylocarpine acetate, catharanthine, tabersonine in Nicotiana benthamiana. ACS Synthetic Biology 12 (1), pp. 27 - 34 (2023)

Hong, B.; Grzech, D.; Caputi, L.; Sonawane, P. D.; Rodriguez Lopez, C. E.; Kamileen, M. O.; Hernández-Lozada, N. J.; Grabe, V.; O’Connor, S. E.: Biosynthesis of strychnine. Nature 607, pp. 617 - 622 (2022)

Boccia, M.; Grzech, D.; Lopes, A. A.; O’Connor, S. E.; Caputi, L.: Directed biosynthesis of new to nature alkaloids in a heterologous Nicotiana benthamiana expression host. Frontiers in Plant Science 13, 919443 (2022)

Yamamoto, K.; Grzech, D.; Koudounas, K.; Stander, E. A.; Caputi, L.; Mimura, T.; Courdavault, V.; O’Connor, S. E.: Improved virus-induced gene silencing allows discovery of a serpentine synthase gene in Catharanthus roseus. Plant Physiology 187 (2), pp. 846 - 857 (2021)

Carqueijeiro, I.; Langley, C.; Grzech, D.; Koudounas, K.; Papon, N.; O’Connor, S. E.; Courdavault, V.: Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs. Current Opinion in Biotechnology 65, pp. 17 - 24 (2020)

Grzech, D.: Elucidation and engineering of two distinct plant terpene alkaloid biosynthetic pathways. Dissertation, Friedrich Schiller University Jena, Jena (2024)